The prophet, Al Mustafa, has lived in the city of Orphalese for 12 years and is about to board a ship which will carry him home. He is stopped by a group of people, with whom he discusses topics such as life and the human condition. The book is divided into chapters dealing with love, marriage, children, giving, eating and drinking, work, joy and sorrow, houses, clothes, buying and selling, crime and punishment, laws, freedom, reason and passion, pain, self-knowledge, teaching, friendship, talking, time, good and evil, prayer, pleasure, beauty, religion, and death.

It was originally published in 1923 by Alfred A. Knopf. It is Gibran's best known work. The Prophet has been translated into over 100 different languages, making it one of the most translated books in history, and it has never been out of print.