This book constitutes the proceedings of the 18th International Conference on Unconventional Computation and Natural Computation, UCNC 2019, held in Tokyo, Japan, in June 2019.

The 19 full papers presented were carefully reviewed and selected from 32 submissions. The papers cover topics such as hypercomputation; chaos and dynamical systems based computing; granular, fuzzy and rough computing; mechanical computing; cellular, evolutionary, molecular, neural, and quantum computing; membrane computing; amorphous computing, swarm intelligence; artificial immune systems; physics of computation; chemical computation; evolving hardware; the computational nature of self-assembly, developmental processes, bacterial communication, and brain processes.