In the tapestry of the 21st century, where technological innovation weaves itself into the very fabric of our lives, a new and intricate thread has emerged: e-substances. These modern marvels—e-cigarettes, synthetic drugs, and digital drugs—represent a convergence of science, culture, and human behavior that both fascinates and alarms me as an educator and researcher. My journey into this domain began with a profound realization: technology, while a beacon of progress, casts long shadows of complexity that demand our attention. Understanding Modern Trends in E-Substances and Their Impact is not just a book—it is my endeavor to illuminate these shadows, to explore the duality of promise and peril that defines this new frontier of substance use.