This issue of Clinics in Podiatric Medicine and Surgery, guest edited by Dr. Adam Landsman, will cover a number of topics surrounding the use of Biologics in Foot and Ankle Surgery. Article content includes, but is not limited to: Use of decellularized collagen for resurfacing of the 1st Metatarsal head; Living cryopreserved bone allograft as an adjunct for hindfoot arthrodesis; Synthetic polycaprolactone grafts as an alternative to decellularized collagen for reinforcement of Achilles and posterior tibial tendons; Cartilage substitutes; allograft, acellular and cellular options for osteochondral defects; Cryopreserved living umbilical cord graft for repair of tendon ruptures; Update on the use of decellularized collagen for surgical repair of tendons; The role of amniotic tissue in the prevention of tendon adhesions during surgical repair; and Stem cells can be used to reduce joint pain in the foot and ankle.