​​​​Preface.- Novel Biclustering Methods for Re-Ordering Data Matrices (P.A. DiMaggio Jr., A. Subramani, C.A. Floudas).- Clustering Time Series Data with Distance Matrices (O. Şeref, W.A. Chaovalitwongse).- Mathematical Models of Supervised Learning and Application to Medical Diagnosis (R. De Asmundis, M.R. Guarracino).- Predictive Model for Early Detection of Mild Cognitive Impairment and Alzheimer's Disease (E.K. Lee, T.-L. Wu, F. Goldstein, A. Levey).- Strategies for Bias Reduction in Estimation of Marginal Means with Data Missing at Random (B. Chen, R.J. Cook).- Cardiovascular Informatics: A Perspective on Promises and Challenges of IVUS Data Analysis (I.A. Kakadiaris, E.G.M. Ruiz).- An Introduction to the Analysis of Functional Magnetic Resonance Imaging Data (G. Gazzola, C.-A. Chou, M.K. Jeong, W.A. Chaovalitwongse).- Sensory Neuroprostheses: From Signal Processing and Coding to Neural Plasticity in the Central Nervous System (F. Panetsos, A. Sanchez-Jimenez, C. Herrera-Rincon).- EEG Based Biomarker Identification Using Graph-Theoretic Concepts: Case Study in Alcoholism (V. Sakkalis, K. Marias).- Maximal Connectivity and Constraints in the Human Brain (R.V. Belavkin).​